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The cancer-associated systemic inflammatory response is one of the critical indicators of tumor progression. Serum systemic inflammatory markers, such as neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, systemic inflammation score, Glasgow prognostic score, prognostic nutritional index, C-reactive protein-albumin ratio, lymphocyte-C-reactive protein ratio, platelet-lymphocyte ratio, are associated with the prognosis of colorectal cancer (CRC) . Further research of the prognostic value of inflammatory marks in CRC can provide help for the prognosis of CRC.
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Objective:To evaluate the clinical value of 3.0 MRI imaging in evaluating the circumferential margin of rectal cancer.Methods:From March 2016 to May 2018, 105 cases of rectal cancer with definite pathology in Shaoxing People's Hospital were evaluated by preoperative MRI and post-operative pathology.The accuracy, sensitivity, specificity, positive predictive value and negative predictive value were obtained.Results:The accuracy, sensitivity, specificity, positive predictive value and negative predictive value were 87.62%(92/105), 50.00%(1/2), 88.35%(91/103), 7.69%(1/13)and 98.91%(91/92), respectively.Conclusion:The accuracy of MRI in evaluating CRM is higher, the specificity and negative predictive value are higher, while the sensitivity and positive predictive value are lower.The reason is related to enlarging the resection scope during operation.Whether it will affect the prognosis of patients needs further follow-up results.
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Objective To investigate the effect of diosmin on the pain and wound healing after modified anal fissure resection .Methods 98 patients from January 2015 to July 2016 in our hospital who were admitted to meet the inclusion criteria and improved anal fissure resection patients were selected and randomly divided into control group and study group, 49 cases in each group.And the control group was given routine postoperative treatment, the study group was treated with diosmin tablets on routine postoperative therapy , two groups were treated for seven days for a course of treatment, the wound pain, wound width and wound healing were observed and recorded before and after treatment, blood samples were taken to determine changes in serum inflammatory factors, the clinical efficacy and complications were compared.Results After treatment, the two groups of wound pain, the width of the wound and wound healing rate were decreased, the serum TNF-α, IFN-γ, IL-6 levels were decreased, the difference was statistically significant (P<0.05), compared with the control group, the degree of pain, the width of the wound and wound healing rate were lower, the serum TNF-α, IFN-γ, IL-6 content were lower, the average healing time and granulation growth time and remove decay time were shorter, the difference was statistically significant (P<0.05).The effective rate of the study group was 91.83%, higher than the control group 75.51%, the difference was statistically significant (P<0.05).All patients were followed up, no case falls off phenomenon, there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Diosmin tablets on the improvement of anal fissure after resection of wound healing has a role in promoting inflammation, reduce the severity of pain conditions.
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ObjectiveTo compare the results of laparoscopic and open radical operation for rectal cancer.MethodsThree hundred and twelve patients with laparoscopic operation and 226 cases with open operation during the period of June 2004 to August 2009 were included.The long-term survival,operative data,postoperative recovery and complications were compared between the two grougs.ResultsThere were no significant differences in age,sex,tumor stage and histologic types between the two groups.The 3 and 5- year-survival rate was 84.5％ and 66.7％ in laparoscopic group,83.3％ and 64.8％ in traditional operation group with no significant difference by Life-table method.The intraoperative blood loss in laparoscopic group was obviously less than that in open group (61 ± 13 nl vs 174 ±84 ml,t =23.24,P ＜0.05).The time of p assage of gas by anus and hospital stay in laparoscopic group were significantly shorter than those in openg roup (2.7 ±1.3 d vs 3.6 ±1.8 d,t =6.61,P ＜0.05;9.1 ±2.4 d vs 12.0 ±3.4 d,t =11.8,P ＜0.05).No significant difference was observed between the two groups in the lymph nodes clearance ( 11.0 ± 2.7 vs 12±3.6,t=1.72,P ＞0.05),specimen length (16.0 ±3.4 cm vs 16.0 ±4.3 cm,t =0,P＞0.05) and distal margin (3.2 ± 1.3 cm vs 3.2 ± 1.7 cm,t =0,P ＞0.05).Surgical site infection of incision developedin 28casesinopensurgerygroupandin8casesinlaparoscopicgroup(P＜ 0.05 ).ConclusionsLaparoscopic surgery for rectal cancer can achieve similar long-term survival as conventional laparotomy with minimal invasion,quicker recovery and less complications.
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Objective To evaluate the effects of intrarectal chemotherapy for advanced unresectable rectal carcinoma.Methods 86 cases of advanced unresectable rectal carcinoma were divided into two groups. The intrarectal chemotherapy group consisted of 43 cases to whom 5 fluorouracil or fluorouracil polyphase liposome oral liquid were administered by rectoclysis, and extract of Chinese herbs was administered as a adjuvant simultaneously. In the control group there were 43 cases who received oral administration of tegafuri(FT 207) or Fluorouracil polyphase liposome and adjuvant Chinese herbs.[WT5”HZ]Results [WT5”BZ] In the intrarectal chemotherapy group mean survial time was 18 2 months, 8 4 months longer than that in the control group ( SD =0 67, t =12 54, P